(此書已包含COVID-19內容)

內容簡介

Basic Virology, 4^th Edition cements this series’ position as the leading introductory virology textbook in the world. It’s easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

This undergraduate-accessible book covers all the foundational topics in virology, including:

• The basics of virology
• Virological techniques
• Molecular biology
• Pathogenesis of human viral disease

The 4^th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.

作者簡介

Dr. Martinez Hewlett is Professor Emeritus of Molecular and Cellular Biology at the University of Arizona

Dr. David Bloom is Professor of Molecular Genetics and Microbiology

Dr. David Camerini is a Project Scientist,Infectious Disease at the University of California, Irvine School of Medicine

目次

Preface

Acknowledgements      

PART I             VIROLOGY AND VIRAL DISEASE   

Chapter 1          Introduction – The Impact of Viruses on Our View of Life         

Chapter 2          An Outline of Virus Replication and Viral Pathogenesis

Chapter 3          Virus Disease in Populations and Individual Animals

Chapter 4          Patterns of Some Viral Diseases of Humans     

PART II           BASIC PROPERTIES OF VIRUSES AND VIRUS–CELL INTERACTION           

Chapter 5          Virus Structure and Classification         

Chapter 6          The Beginning and End of the Virus Replication Cycle  

Chapter 7          The Innate Immune Response: Early Defense Against Pathogens

Chapter 8          Strategies to Protect Against and Combat Viral Infection

PART III          WORKING WITH VIRUS

Chapter 9          Visualization and Enumeration of Virus Particles           

Chapter 10        Replicating and Measuring Biological Activity of Viruses         

Chapter 11        Physical and Chemical Manipulation of the Structural Components of Viruses

Chapter 12        Characterization of Viral Products Expressed in the Infected Cell

Chapter 13        Viruses Use Cellular Processes to Express their Genetic Information

PART IV          REPLICATION PATTERNS OF SPECIFIC VIRUSES

Chapter 14        Replication of PositiveSense RNA Viruses

Chapter 15        Replication Strategies of RNA Viruses Requiring RNAdirected mRNA Transcription as the First Step in Viral Gene Expression

Chapter 16        Replication Strategies of Small and Mediumsized DNA Viruses

Chapter 17        Replication of Some Nuclearreplicating Eukaryotic DNA Viruses with Large Genomes

Chapter 18        Replication of Cytoplasmic DNA Viruses and “Large” Bacteriophages

Chapter 19        Retroviruses: Converting RNA to DNA

Chapter 20        Human Immunodeficiency Virus Type 1 (HIV1) and Related Lentiviruses

Chapter 21        Hepadnaviruses: Variations on the Retrovirus Theme

PART V           MOLECULAR GENETICS OF VIRUSES

Chapter 22        The Molecular Genetics of Viruses

Chapter 23        Molecular Pathogenesis

Chapter 24        Viral Bioinformatics

Chapter 25        Viruses and the Future – Problems and Promises

Appendix – Resource Center    

Technical Glossary

Index