Apoptosis and Autoimmunity:From Mechanisms to Treatments 2003
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$ 2,450
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$ 1,000
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Apoptosis and Autoimmunity:From Mechanisms to Treatments 2003-需求單
內容簡介
This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases.
It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
目次
PART 1: GENERAL FEATURES OF APOPTOSIS.
CHAPTER 1. Apoptosis and Autoimmunity / Keith Elkon
CHAPTER 2. Caspase Knockouts: Matters of Life and Death / Saquib Lakhani, Binfeng Lu, Richard A. Flavell
PART 2: CLEARANCE OF APOPTOTIC CELLS.
CHAPTER 3. Anti-Inflammatory and Immunoregulatory Effects of Apoptotic Cells / Reinhard E. Voll, Dr. Dr. Martin Herrmann, Irute Girkontaite, Christian Stach, Wasilis Kolowos, Prof. Dr. Dr. Joachim R. Kalden
CHAPTER 4. Complement and Apoptosis / Dror Mevorach
CHAPTER 5. Soluble Factors That Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies / Patrizia Rovere-Querini
CHAPTER 6. The Role of ATP-Binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems / Véronique Rigot, Giovanna Chimini
CHAPTER 7. Innate Immunity and Apoptosis: CD14-Dependent Clearance of Apoptotic Cells / Christopher D. Gregory, Andrew Devitt
PART 3: AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS.
CHAPTER 8. Autoimmune Lymphoproliferative Syndromes / Frédéric Rieux-Laucat, Françoise Deist, Alain Fischer
CHAPTER 9. Infection and Inflammation as Cofactors for Autoimmunity of Systemic Lupus Erythematosus Patients / Hanns-Martin Lorenz
CHAPTER 10. Apoptosis in Rheumatoid Arthritis / Yuji Yamanishi, Gary S. Firestein
CHAPTER 11. Systemic Lupus Erythematosus / Thomas D. Beyer, Susanne Kuenkele, Udo S. Gaipl, Wasilis Kolowos, Reinhard E. Voll, Irith Baumann, Prof. Dr. Dr. Joachim R. Kalden, Dr. Dr. Martin Herrmann
PART 4: IMMUNOGENICITY OF APOPTOTIC CELLS.
CHAPTER 12. Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines / Lars Jenne, Birthe Sauter
CHAPTER 13. The Immune Response against Apoptotic Cells / Angelo A. Manfredi
PART 5: "ALTERED SELF" IN DYING CELLS.
CHAPTER 14. Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease / Antony Rosen, Livia Casciola-Rosen
CHAPTER 15. Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity / Carlos A. Casiano, Christine Molinaro, Sheldon Holder, Xiwei Wu
CHAPTER 16. 'Tissue' Transglutaminase and Autoimmunity / Alessandra Amendola, Mauro Piacentini
CHAPTER 17. Modification of RNA Antigens in Apoptosis / Wolfgang Hueber, Paul J. Utz
PART 6: THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY.
CHAPTER 18. Nucleosomes and Anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus / Jürgen W. C. Dieker, Johan van der Vlag, Jo H. M. Berden
Glossary
Subject Index
ISBN-13碼 :
9783527304424
ISBN-10碼 :
3527304428
出版日期 :
2003
書系代碼 :
23100
作者 :
Joachim R. Kalden．Martin Herrmann
開數 :
18開
頁數 :
381
裝訂 :
精裝
定價 :
NT$2,450.00
