Stem Cell Therapeutics for Cancer 2013
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內容簡介
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
• Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
• Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
• Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types.
作者簡介
Khalid Shah, MS, PhD is an Associate Professor of Neurology and Radiology at Massachusetts General Hospital Harvard Medical School, where he also directs the Molecular Neurotherapy and Imaging Lab and the Stem Cell Imaging and Therapeutics Program. In addition to Dr. Shah's teaching and directorial activities, he is also a member of the editorial board for Nature Medicine, PNAS, Journal of Clinical Investigation, Stem Cells and Nature Neuroscience.
目次
Section 1: Introduction.
CHAPTER 1 Stem Cell Sources and Their Potential for Cancer Therapeutics / Khalid Shah
Section 2: Migration and fate of stem cells.
CHAPTER 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration / Moneeb Ehtesham, Elliot Min, and Rebecca Kasl
CHAPTER 3 Tumor tropism of mesenchymal stem cells / Paula Y.P. Lam and Ivy A.W. Ho
Section 3: Stem cell therapy in brain cancer.
CHAPTER 4 Stem cell-mediated TRAIL therapy for highly aggressive brain tumors / Khalid Shah
CHAPTER 5 Stem cell-mediated prodrug gene therapy of high-grade brain tumors / Cestmir Altaner
CHAPTER 6 Role of naïve cord blood stem cells in glioma therapy / Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S. Rao
CHAPTER 7 Stem cell-based antiangiogenic therapies for brain tumors / Navid Redjal and Khalid Shah
CHAPTER 8 Treatment of metastatic neuroblastoma with mesenchymal stem cell-based oncolytic virotherapy / Manuel Ramírez and Javier García-Castro
Section 4: Stem cell therapy in other cancer types.
CHAPTER 9 Umbilical cord matrix stem cells for cytotherapy of breast cancer / Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, and Masaaki Tamura
CHAPTER 10 Mesenchymal stromal cells as effective tumor antigen-presenting cells in cancer therapeutics / Raphaëlle Romieu-Mourez and Jacques Galipeau
CHAPTER 11 Diagnostic and therapeutic mesenchymal stem cells for breast cancer treatment / Róisín Dwyer
CHAPTER 12 Genetically engineered stem cell therapies targeting gastrointestinal malignancy / Emily Keung, Peter J. Nelson, and Claudius Conrad
CHAPTER 13 Mesenchymal stem cells in prostate cancer: clinical opportunities / Diptiman Chanda and Selvarangan Ponnazhagan
CHAPTER 14 Primed mesenchymal stromal cells for cancer therapy / Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini, and Giulio Alessandri
Section 5: Combinatorial stem cell therapies.
CHAPTER 15 MicroRNA adjuvants in stem cell-based cancer therapy / Maarten C.J. Anderegg and Maarten F. Corsten
CHAPTER 16 Stem cell-based combination therapies for cancer: systemic delivery of a PI K/mTOR inhibitor (PI-103) and stem cell-mediated delivery of TRAIL in brain tumors / Tugba Bagci-Onder
CHAPTER 17 The efficacy of clinically approved agents with stem cell-delivered therapeutics for cancer therapy / Hiroaki Wakimoto and Khalid Shah
Section 6: Tracking stem cells and stem cell-based therapeutics.
CHAPTER 18 Imaging migration and fate of stem cells in experimental models of cancer / Deepak Bhere and Khalid Shah
CHAPTER 19 Multifunctional molecules for interrogating stem cell-based therapeutics / Shawn Hingtgen
CHAPTER 20 Tracking cancer-targeted MSC with PET imaging / Véronique Roelants and Jean-Louis Vanoverschelde
Index
ISBN-13碼 :
9781118282427
出版日期 :
2013
書系代碼 :
9781118282427
作者 :
Khalid Shah
開數 :
16開
頁數 :
304
裝訂 :
精裝
定價 :
1450