Structural Biology Using Electrons and X-rays is the perfect book to provide advanced undergraduates or graduate students with an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starting with Fourier transforms and progressing through optics and imaging principles, symmetry and three-dimensional reconstruction theory, Structural Biology Using Electrons and X-rays ends in an account of the latest methods adapted to crystals, helices, viral heads, and single particles.

 

This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics.

 

Key features:

• Emphasis on common principles underlying all diffraction-based methods

• Thorough grounding in theory requires understanding of only simple algebra

• Visual representations and explanations of challenging content

• Mathematical detail offered in short-course form to parallel the text

Michael Moody has worked in leading laboratories in the United States and Europe and taught at many international electron-microscopy image-analysis courses.